https://www.astersteroids.com/type-2-diabetes-treatment-semaglutide-wegovy-fda-approved-for-healthy-weight-loss/
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Peptides Semaglutide is a glucagon-like peptide 1 (GLP-1) receptor agonist. Currently, we know that there are three products approved by the US FDA that contain semaglutide: Ozempic, Rybelsus and Wegovy. Among them, Ozempic and Rybelsus are mainly use for type 2 diabetes, and Wegovy(Semaglutide) use for weight loss.
Details as below:
What is GLP-1?
GLP-1, or glucagon-like peptide-1, is a hormone that naturally producing in the body. It mainly produce in the gut. GLP-1 plays a crucial role in regulating blood sugar levels and appetite.
In consuming food, GLP-1releasing into the blood, and it has several effects on the body.
Stimulates insulin release: GLP-1 enhances insulin release. Insulin lowers blood sugar levels by encouraging glucose to enter cells.
Inhibition of glucagon release: GLP-1 inhibits the release of glucagon, another hormone produced by the pancreas. Glucagon raises blood sugar levels by promoting the release of stored glucose in the liver.
Slow gastric emptying: GLP-1 slows the rate at which the stomach dumps its contents into the intestines. This delay in gastric emptying helps reduce the rapid rise in blood sugar levels after a meal.
Appetite suppression: GLP-1 acts on the brain to suppress appetite and promote satiety.
Given these roles, GLP-1 plays a crucial role in regulating glucose metabolism in the body and promoting glucose control. Development of GLP-1 receptor agonists that can mimic the effects of GLP-1 to improve blood sugar control and weight loss in patients with type 2 diabetes or obesity. That’s what Semaglutide is like.
How Semaglutide works?
Peptides Semaglutide, first use to treat type 2 diabetes and obesity, acts as a GLP-1 receptor agonist by mimicking GLP-1 action.
When inject Semaglutide, it binds to and activates GLP-1 receptors locating on various cells in the body, including pancreatic cells.
By stimulating the release of insulin, glucose in the blood encourage to enter cells, thereby lowering blood sugar levels. Sugars that enter the cell also provide energy to the cell;
By inhibiting glucagon, the liver does not produce excess glucose, thereby reducing blood sugar levels.
By slowing stomach emptying, it reduces the rate at which nutrients, including glucose, are absorbed into the bloodstream, helping to control blood sugar spikes after meals. This effect prevents people from feeling hungry as soon as possible and does not produce the desire to eat, which helps people with type 2 diabetes or obesity control their appetite.
Semaglutide also affects appetite regulation centers by acting on the brain, resulting in reduced hunger and increased feelings of gulping. Helps to control appetite and lose weight.
Overall, Semaglutide helps improve blood sugar control in people with type 2 diabetes by increasing insulin release, inhibiting glucagon secretion, and slowing digestion, while having the effect of reducing weight control.
